Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein
نویسندگان
چکیده
منابع مشابه
Calcium/calmodulin-dependent protein kinase II.
There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from other tissues appear to behave in a broadl...
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The search for “memory molecules” and why CaMKII is an appealing candidate Since the time neuroscientists first recognized that biochemical events inside neurons could influence the function of the brain, there have been people looking for “memory molecules.” This elusive ion, small molecule, protein, or nucleic acid would be the keystone on which memory was built; understanding the memory mole...
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The introduction of several mutations resulted in the generation of improved mutants of the green fluorescent protein (GFP). A strong green (GFPsg25) and blue (BFPsg50) fluorescent protein, gave 50-fold-100-fold brighter fluorescence compared to wild-type GFP and BFP (Tyr66His), respectively, upon expression in mammalian cells. GFPsg25 and BFPsg50 have different excitation and emission maxima. ...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2008
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2007.10.014